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Old 05-01-2011, 01:02 AM   #1
baohua100
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Location: Canada

Join Date: Jun 2008
Posts: 103
Default allele-specific expression by direct genome and transcritpome sequencing

We sequenced the diploid genome of a single individual and their transcritome.
(Poplar)

Fisrt, we identiy all the heterozygosity SNPs (genome).

If i know it's a heterozygosity SNPs, Should I do a chi square test using the number (65,89,38,28) or do a bionomal test (50,50,38,28) ?

an example of heterozygosity SNP (The numbers are counts of the two alleles observed in gDNA or cDNA)

gDNA cDNA
A 65 38
G 89 28
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