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Old 03-04-2011, 12:47 PM   #1
Michael.James.Clark
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Location: Palo Alto

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Posts: 213
Default Trimming SOLiD data pre-alignment

Hi everyone,
Regarding SOLiD4, I'm curious if people still typically trim the ends of reads pre-alignment.
We used to trim five bases off the ends of all the reads pre-alignment with SOLiD3 data to avoid complications with variant calling due to low quality calls at the ends.
Thanks.
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