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Old 06-07-2011, 06:33 AM   #1
happy2000
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Question calculation of sensitivity and specificity

Hello everyone,
I want to do an evaluation of a pattern search tool. For that I want to calculate sensitivity and specificity.
How can I determine the true positives and false positives, the real pattern (verified experimentally) are not all known. And how can I calculate the sensitivity and specificity.
Cordially
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Old 06-07-2011, 12:38 PM   #2
JohnK@Genome_Quest
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If you're experimentally verifying the real patterns, I imagine you could confirm your True Positives by comparing them to your experimentally-validated pattern data. As for your False Positives, they might be those that don't overlap with your experimentally-validated data. I think wikipedia gives a good article on how to calculate sensitivity/specificity as well as the calculations:

http://en.wikipedia.org/wiki/Sensiti...nd_specificity
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Old 06-07-2011, 12:42 PM   #3
happy2000
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Thank you very much JohnK@Genome
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Old 06-10-2011, 05:26 AM   #4
happy2000
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Question

Hello,
For confirm True Positives by comparing them to experimentally-validated pattern data.
I must put the annotated binding sites in their genomic context.
Please, have you any idea how to do that ?
Cordially
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