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Old 12-27-2011, 02:00 AM   #1
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Default PubMed: ART: a next-generation sequencing read simulator.

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ART: a next-generation sequencing read simulator.

Bioinformatics. 2011 Dec 23;

Authors: Huang W, Li L, Myers JR, Marth GT

Abstract
SUMMARY: ART is a set of simulation tools that generate synthetic next-generation sequencing reads. This functionality is essential for testing and benchmarking tools for next-generation sequencing data analysis including read alignment, de novo assembly, and genetic variation discovery. ART generates simulated sequencing reads by emulating the sequencing process with built-in, technology-specific read error models and base quality value profiles parameterized empirically in large sequencing datasets. We currently support all three major commercial next-generation sequencing platforms: Roche's 454, Illumina's Solexa, and Applied Biosystems' SOLiD.ART also allows the flexibility to use customized read error model parameters and quality profiles. AVAILABILITY: Both source and binary software packages are available at http://www.niehs.nih.gov/research/re...s/software/art. CONTACT: WH at weichun.huang@nih.gov or GTM at gabor.marth@bc.edu.


PMID: 22199392 [PubMed - as supplied by publisher]



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