Maternal vs Zygotic gene expression

[SuzuBell]

Are there any studies demonstrating evidence of zygotic mRNA showing greater gene expression than maternal mRNA (after "maternal to zygotic transition") that could affect results from RNA-seq analysis etc.? Anyone have experiences like this?

Thanks!

[mbblack]

I would think you would need to identify which organism you are interested in. Are you referring to the zygote in a strict literal sense, or also morula stages (ie. in mammals, would you include anything pre-blastocyst?).

You could start from http://genomebiology.com/2010/11/6/r58 as there seems plenty of literature on the subject. But you might want to narrow your search by taxon at least.

P.S. you might also want to get a hold of http://www.ncbi.nlm.nih.gov/pubmed/25239944 - a reviews the use of "...single-cell transcriptomics applied to mouse preimplantation embryo blastomeres...".