Hello,
I am looking for documentation about the correlation between sequencing depth and false discovery rate.
I mean, if there is a SNPs at a position and if the coverage at this position is low, is the probability to detect this snp lower than if the coverage was high ?
Or if a differentially expressed gene has a low coverage on the average, is the probability to detect the gene as differentially expressed lower than if the coverage was high?
Do you know if there are studies or papers about this point?
Thanks in advance,
Jane
I am looking for documentation about the correlation between sequencing depth and false discovery rate.
I mean, if there is a SNPs at a position and if the coverage at this position is low, is the probability to detect this snp lower than if the coverage was high ?
Or if a differentially expressed gene has a low coverage on the average, is the probability to detect the gene as differentially expressed lower than if the coverage was high?
Do you know if there are studies or papers about this point?
Thanks in advance,
Jane
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