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Old 02-05-2013, 06:17 AM   #1
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Location: Pol

Join Date: Jan 2013
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Default Structural Variants simulator

In order to test SV detection tool I want to create SV simulation pipeline.

SNP/Indelīs can be generated using wgsim and I am looking for a similar tool but for generating SVīs.

Emboss msbar is really nice - "changes a sequence, attempting to emulate various forms of mutation". It can introduce deletions, duplications, insertions randomly.

1. Does anybody know a tool/script that can generate SVīs (deletions, duplications, inversions) non randomly - "from .. to" given range. I need to know exact breakpoint position.
2. What read simulator should I use for SVīs detection? Is wigsim is still worth trying. I know ReseqSim, but their might be some more.

Hope, someone can help me with this.

Last edited by Povillasgi; 02-05-2013 at 06:19 AM.
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simulating sequence data, structural variants

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