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Old 09-22-2016, 03:24 AM   #1
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Default How to use f statistics test in snp panal data?


I am doing admixture analysis. How can I do f statistics test in snp panal data?
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Old 11-14-2021, 10:36 PM   #2
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First, we examine the joint distribution of a pair of SNPs in cases and controls separately. Second, an F-test is used to evaluate the ratio of dependence in cases to that of controls. Finally, results are adjusted for multiple tests. This method was used to evaluate gene-gene interactions that are associated with risk of Type 2 Diabetes among African Americans in the Howard University Family Study. We identified 18 gene-gene interactions (P < 0.0001). Compared with the commonly-used logistical regression method, we demonstrate that the F-ratio test is an efficient approach to measuring gene-gene interactions, especially for studies with limited sample size.
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