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Old 01-11-2016, 12:56 PM   #1
sic
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Default Alternatives to Broad's DAPPLE tool

Hi everyone

I have a set of coding variants, on which I want to run some protein protein interaction tools. I've used a couple of resources so far (String, CPDB), and I really want to use Broad's (online) DAPPLE tool. Unfortunately it's been down for some time now, and I can't get a hold of the tool's developers, nor can I find any sources to download so I can run it locally.

My questions - is there anyone here that has used this tool? Could anyone recommend a similar tool, or does anyone have source I could install/run locally?

For reference I've attached a screenshot of a figure generated by DAPPLE, from Neale et al's 2012 article "Patterns and rates of exonic de novo mutations in autism spectrum disorders".

Thank you!
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File Type: png Neale2012_DAPPLE.png (57.7 KB, 4 views)
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broad institute, interaction, pathway analysis, protein clustering

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