I need reads data with called variants that's been validated

dopadelic · 05-05-2017, 09:37 AM

I'm looking to develop methods to improve variant calling accuracy. I need an open dataset with the reads. Pre-aligned data such as with pileup files are ok.

I would need the variants contained in the reads to be validated by some gold standard. (perhaps with Sanger?)

Is there such a dataset available to the public?

Richard Finney · 05-05-2017, 02:07 PM

Check out "Genome in a Bottle" :
https://github.com/genome-in-a-bottle/giab_FAQ

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05-05-2017, 09:37 AM	#1
dopadelic Junior Member Location: California Join Date: May 2017 Posts: 1	I need reads data with called variants that's been validated I'm looking to develop methods to improve variant calling accuracy. I need an open dataset with the reads. Pre-aligned data such as with pileup files are ok. I would need the variants contained in the reads to be validated by some gold standard. (perhaps with Sanger?) Is there such a dataset available to the public?

05-05-2017, 02:07 PM	#2
Richard Finney Senior Member Location: bethesda Join Date: Feb 2009 Posts: 700	Check out "Genome in a Bottle" : https://github.com/genome-in-a-bottle/giab_FAQ