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Old 10-16-2008, 06:00 AM   #1
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Default PubMed: SNP frequency estimation using massively parallel sequencing of pooled DNA.

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SNP frequency estimation using massively parallel sequencing of pooled DNA.

Eur J Hum Genet. 2008 Oct 15;

Authors: Ingman M, Gyllensten U

Resequencing of genomic regions that have been implicated by linkage and/or association studies to harbor genetic susceptibility loci represents a necessary step to identify causal variants. Massively parallel sequencing (MPS) offers the possibility of SNP discovery and frequency determination among pooled DNA samples. The strategies of pooling DNA samples and pooling PCR amplicons generated from individual DNA samples were evaluated, and both were found to return accurate estimates of SNP frequencies across varying levels of sequence coverage.European Journal of Human Genetics advance online publication, 15 October 2008; doi:10.1038/ejhg.2008.182.

PMID: 18854868 [PubMed - as supplied by publisher]

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