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Old 08-17-2015, 07:43 AM   #1
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Location: Atlanta

Join Date: Oct 2010
Posts: 4
Default A better way to map sequencing reads using existing read mapping tool

Our group just published a paper on improving sequencing read mapping. We achieved this without inventing a new read alignment tool. The key is to customize the reference genome for each individual since mutation profile on many subjects are known a priori from previous array-based genotyping. Our software tool--RefEditor can work with any existing aligner such as BWA or bowtie.

One Size Doesn't Fit All - RefEditor: Building Personalized Diploid Reference Genome to Improve Read Mapping and Genotype Calling in Next Generation Sequencing Studies

RefEditor is freely available at

steveqin.emory is offline   Reply With Quote

read alignment, read mapping, reference genome

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