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  • calculation of sensitivity and specificity

    Hello everyone,
    I want to do an evaluation of a pattern search tool. For that I want to calculate sensitivity and specificity.
    How can I determine the true positives and false positives, the real pattern (verified experimentally) are not all known. And how can I calculate the sensitivity and specificity.
    Cordially

  • #2
    If you're experimentally verifying the real patterns, I imagine you could confirm your True Positives by comparing them to your experimentally-validated pattern data. As for your False Positives, they might be those that don't overlap with your experimentally-validated data. I think wikipedia gives a good article on how to calculate sensitivity/specificity as well as the calculations:

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    • #3
      Thank you very much JohnK@Genome

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      • #4
        Hello,
        For confirm True Positives by comparing them to experimentally-validated pattern data.
        I must put the annotated binding sites in their genomic context.
        Please, have you any idea how to do that ?
        Cordially

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