tools/approaches to detect mutated pathways

mrfox · 11-05-2015, 07:30 PM

hi all,

I have exome sequencing data of 50 patients. And my collaborator is specifically interested in a pathway including about 30 genes. I wonder if there is recommendation about the tool to detect significantly mutated (or malfunctioned) pathway(s).

I am trying HotNet2. Any other suggestions?

Thank you!

Richard Finney · 11-05-2015, 07:49 PM

Dump your gene names into this ...

https://david.ncifcrf.gov/

"DAVID now provides a comprehensive set of functional annotation tools for investigators to understand biological meaning behind large list of genes."

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11-05-2015, 07:30 PM	#1
mrfox Senior Member Location: USA Join Date: Aug 2010 Posts: 103	tools/approaches to detect mutated pathways hi all, I have exome sequencing data of 50 patients. And my collaborator is specifically interested in a pathway including about 30 genes. I wonder if there is recommendation about the tool to detect significantly mutated (or malfunctioned) pathway(s). I am trying HotNet2. Any other suggestions? Thank you!

11-05-2015, 07:49 PM	#2
Richard Finney Senior Member Location: bethesda Join Date: Feb 2009 Posts: 700	Dump your gene names into this ... https://david.ncifcrf.gov/ "DAVID now provides a comprehensive set of functional annotation tools for investigators to understand biological meaning behind large list of genes."