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Old 04-28-2015, 01:19 AM   #1
bryand
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Location: Goettingen, Germany

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Default DESeq2 - Log2fc when all expression is 0 in one group?

Hi all,

So I've got an experiment where for certain experimental reasons, there is absolutely no expression in one group of some genes and robust expression in the other group. Yet DESeq2 reports a log2fc score - how is that calculated? Is there some kind of pseudocount added to a term?
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Old 04-28-2015, 07:24 AM   #2
Michael Love
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Default

hi,

here's an answer i posted on the bioc support site to the same question

https://support.bioconductor.org/p/64014/#64016
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