Dear forum-members,
I've had a puzzling reply by a reviewer on the claim that:
"Differences in the accurary of assembly between heterogeneous 454- transcriptome reads between de bruijn and OLC based methods can be expected due to the different way these two algorithms work."
To this the reviewer responded by saying that "both paradigms have the same mathematical characteristics and there's not inherent advantage to either".
I'm a biologist and not a computer scientist, so pardon me If I'm being ignorant here. Could someone refer me to a good tutorial on this or explain in laymans terms why they think the reviewers response is either right or wrong?
Thanks!
I've had a puzzling reply by a reviewer on the claim that:
"Differences in the accurary of assembly between heterogeneous 454- transcriptome reads between de bruijn and OLC based methods can be expected due to the different way these two algorithms work."
To this the reviewer responded by saying that "both paradigms have the same mathematical characteristics and there's not inherent advantage to either".
I'm a biologist and not a computer scientist, so pardon me If I'm being ignorant here. Could someone refer me to a good tutorial on this or explain in laymans terms why they think the reviewers response is either right or wrong?
Thanks!
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