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  • ERC-funded postdoc position - regulatory genomics in flies

    An ERC-funded postdoc position is available in our lab (IGFL, Lyon, France) to work on regulatory genomis in Drosophila embryos using single-cell genomics technics.
    More info:
    The Ghavi-Helm Laboratory for developmental epigenetics. 3D regulatory genomics during Drosophila embryogenesis. In eukaryotes, the complex regulation of temporal- and tissue-specific gene expression is controlled by the binding of transcription factors to enhancers, which in turn interact with the promoter of their target gene(s) via the formation of a chromatin loop. Despite their importance, the properties governing enhancer function and enhancer-promoter loops in the context of the three-dimensional organization of the genome are still poorly understood. In this context, my group will apply an interdisciplinary approach, combining state-of-the-art methods in genetics and genomics, including novel single-cell techniques, using Drosophila embryogenesis as a model system. Our results will provide a unique view of the functionality of enhancer-promoter interactions in a developing embryo, a significant step towards understanding the link between chromatin organization and transcription regulation.

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