hi, everyone, I am a new one in this area.
now I plan to use this method to study a TF binding sites.
I prepare two biological replicates, but whether I need a negative control sequencing?
I read some paper, and say there are two case can choose:
one-sample analysis where only a ChIP'd sample is sequenced
two-sample analysis, where both a ChIP'd sample and a negative control sample
I was a little confused and want to hear your opinion.
thanks very much
now I plan to use this method to study a TF binding sites.
I prepare two biological replicates, but whether I need a negative control sequencing?
I read some paper, and say there are two case can choose:
one-sample analysis where only a ChIP'd sample is sequenced
two-sample analysis, where both a ChIP'd sample and a negative control sample
I was a little confused and want to hear your opinion.
thanks very much
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