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Old 08-17-2015, 07:43 AM   #1
steveqin.emory
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Location: Atlanta

Join Date: Oct 2010
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Default A better way to map sequencing reads using existing read mapping tool

Our group just published a paper on improving sequencing read mapping. We achieved this without inventing a new read alignment tool. The key is to customize the reference genome for each individual since mutation profile on many subjects are known a priori from previous array-based genotyping. Our software tool--RefEditor can work with any existing aligner such as BWA or bowtie.

One Size Doesn't Fit All - RefEditor: Building Personalized Diploid Reference Genome to Improve Read Mapping and Genotype Calling in Next Generation Sequencing Studies
http://journals.plos.org/ploscompbio...l.pcbi.1004448

RefEditor is freely available at
https://github.com/superyuan/refeditor

Steve
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