Go Back   SEQanswers > Literature Watch

Similar Threads
Thread Thread Starter Forum Replies Last Post
choosing & validating RNA-Seq time course data normalization method(s) anandksrao Bioinformatics 6 10-20-2012 11:50 AM
RNA-Seq: Differential expression analysis for sequence count data. Newsbot! Literature Watch 3 09-25-2012 10:19 AM
using NGS, what is the best miRNA expression normalization method? Giorgio C Bioinformatics 4 12-07-2011 07:32 AM
RNA-Seq Quantification and Differential Expression Analysis days369 RNA Sequencing 2 04-06-2011 01:24 AM
RNA-Seq: Cloud-scale RNA-sequencing differential expression analysis with Myrna. Newsbot! Literature Watch 0 08-13-2010 09:00 AM

Thread Tools
Old 03-15-2010, 06:20 AM   #1
Genome Informatics Facility
Location: Iowa @isugif

Join Date: Sep 2009
Posts: 105
Default A scaling normalization method for differential expression analysis of RNA-seq data

Genome Biology 2010, 11:R25 doi:10.1186/gb-2010-11-3-r25
Mark D Robinson (
Alicia Oshlack (

The fine detail provided by sequencing-based transcriptome surveys suggests that RNA-seq is likely to become the platform of choice for interrogating steady state RNA. In order to discover biologically important changes in expression, we show that normalization continues to be an essential step in the analysis. We outline a simple and effective method for performing normalization and show dramatically improved results for inferring differential expression in simulated and publicly available data sets.
severin is offline   Reply With Quote
Old 09-10-2010, 12:09 AM   #2
Junior Member
Location: taipei, taiwan

Join Date: Jul 2010
Posts: 1

thank you for severin provide this information
daniel.liu is offline   Reply With Quote

human, normalization, rna-seq

Thread Tools

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off

All times are GMT -8. The time now is 07:49 PM.

Powered by vBulletin® Version 3.8.9
Copyright ©2000 - 2021, vBulletin Solutions, Inc.
Single Sign On provided by vBSSO