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Thread | Thread Starter | Forum | Replies | Last Post |
choosing & validating RNA-Seq time course data normalization method(s) | anandksrao | Bioinformatics | 6 | 10-20-2012 11:50 AM |
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RNA-Seq: Cloud-scale RNA-sequencing differential expression analysis with Myrna. | Newsbot! | Literature Watch | 0 | 08-13-2010 09:00 AM |
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#1 |
Genome Informatics Facility
Location: Iowa @isugif Join Date: Sep 2009
Posts: 105
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Genome Biology 2010, 11:R25 doi:10.1186/gb-2010-11-3-r25
Mark D Robinson (mrobinson@wehi.edu.au) Alicia Oshlack (oshlack@wehi.edu.au) The fine detail provided by sequencing-based transcriptome surveys suggests that RNA-seq is likely to become the platform of choice for interrogating steady state RNA. In order to discover biologically important changes in expression, we show that normalization continues to be an essential step in the analysis. We outline a simple and effective method for performing normalization and show dramatically improved results for inferring differential expression in simulated and publicly available data sets. http://genomebiology.com/2010/11/3/R25 |
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#2 |
Junior Member
Location: taipei, taiwan Join Date: Jul 2010
Posts: 1
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thank you for severin provide this information
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Tags |
human, normalization, rna-seq |
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