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Old 12-08-2015, 11:53 AM   #1
Qiagen Inc
Registered Vendor
Location: Boston

Join Date: Dec 2015
Posts: 3
Default Senior Scientist, Enzyme Engineering (NGS)

Senior Scientist, Enzyme Engineering, NGS Technologies will be responsible for the development of novel improved enzymes that will be used in Qiagen’s NGS workflows. These enzymes include sequencing enzymes for the sequencing by synthesis processes as well as novel enzymes used for nucleic acids amplification. In this role Senior Scientist, Enzyme Engineering will focus on near and long term improvements to existing Gene Reader workflows as well as perform research on novel internal and external technologies which will expand the range of applications and capabilities supported by future NGS workflows/platforms. The position will have a key role in bringing innovative solutions to current and future NGS platforms and expanding the range of applications served by these platforms. Senior Scientist will be working closely with Sample Prep and Sequencing teams as well as Engineering to ensure seamless integration of novel enzymes into QIAGEN’s NGS portfolio.

In this role Senior Scientist, Enzyme Engineering, NGS Technologies will:

Investigate and develop technologies and approaches (internal and external) to the development of novel sequencing enzymes with improved properties including mutagenesis, in silico design and in vitro evolution which significantly improve performance and capabilities of the Gene Reader workflows

Work closely with Sequencing Chemistry developers to integrate novel sequencing enzymes into the Gene Reader workflows

Evaluate external technologies and engage in external collaborations to bring novel technologies to QIAGEN’s NGS portfolio

Play a key role in the development of future improvements, technological advances in the QIAGEN NGS platform and expansion of intellectual property

Participate in collaborations with key external partners (industry and academia)

Mentor and develop staff

Deliver key insights into product application opportunities for the Qiagen's NGS platforms


PhD in Biology, Chemistry, Biochemistry, Bioengineering or related fields
At least 5-10 years of relevant industry experience (NGS and adjacent technologies)

Extensive experience with protein engineering based on rational design, mutagenesis, in silico design, and enzyme in vitro evolution

Experience with protein purification and enzymatic activity measurements/ assays

Experience with diagnostic assay development and regulatory environment is a plus

Excellent understanding of the underlying technical principles of next generation sequencing chemistries and workflows, associated instrumentation platforms and data analysis and interpretation algorithms

Mandatory experience in next generation sequencing (NGS) technology development (DNA amplification, sample preparation, chemistry, instrumentation)

Very good troubleshooting and problem solving skills

Proven leadership and successful decision-making qualities

Strong technical writing and presentation skills

Moderate travel required (up to 10%)

To apply, please follow the link below

Qiagen is an Equal Opportunity Employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity, status as a veteran, and basis of disability or any other federal, state or local protected class.
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enzyme engineering, ngs, protein engineering, sequencing

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