SEQanswers

Go Back   SEQanswers > Bioinformatics > Bioinformatics



Similar Threads
Thread Thread Starter Forum Replies Last Post
Sequence Read Archive downloads and Aspera iquigley Bioinformatics 4 02-05-2013 12:18 AM
PubMed: The sequence read archive. Newsbot! Literature Watch 0 04-29-2011 03:10 AM
Short Read Archive format problems Ender985 Bioinformatics 7 07-28-2010 12:23 PM
Short Read Archive format dbrami Bioinformatics 2 04-28-2010 01:15 PM
Very Short Read aligner Rupinder Bioinformatics 1 06-02-2009 08:10 PM

Reply
 
Thread Tools
Old 09-28-2011, 02:04 PM   #81
Joann
Senior Member
 
Location: Woodbridge CT

Join Date: Oct 2008
Posts: 231
Default seq more information

Quote:
Originally Posted by srasdk View Post
In resequencing ~90% of raw sequences perfectly match the reference.
1. Will you supply bibliographic citation for this observation?

Quote:
Originally Posted by srasdk View Post
When this cost will be low enough to make archival economically senseless, it will stop.
2. What will do for comparative biological/phylogenetic studies?

Thanks.
Joann is offline   Reply With Quote
Old 09-28-2011, 08:07 PM   #82
srasdk
Member
 
Location: Maryland, USA

Join Date: Jun 2011
Posts: 19
Default

1. The observation is general and not precise. It was done while working with the recent 1000 Genomes data. Sorry - the statement was too broad. Homo sapiens is a very inbred species and any personal germline genome is very close to the reference. Somatic changes (cancer) are more unpredictable. If you are interested in in biological diversity other then human, then you were right in confronting the statement, but currently NGS data production is heavily tilted toward human.

2. Before NGS phylogenetic studies were submitted as final and annotated sequences to GenBank. When community becomes confident that it can extract most of the information from raw data, there will be no point of archiving intermediate results.
srasdk is offline   Reply With Quote
Old 10-20-2011, 11:04 AM   #83
lh3
Senior Member
 
Location: Boston

Join Date: Feb 2008
Posts: 693
Default

http://www.ncbi.nlm.nih.gov/About/news/13Oct2011.html
lh3 is offline   Reply With Quote
Reply

Thread Tools

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off




All times are GMT -8. The time now is 09:11 AM.


Powered by vBulletin® Version 3.8.9
Copyright ©2000 - 2019, vBulletin Solutions, Inc.
Single Sign On provided by vBSSO