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Old 09-28-2011, 02:04 PM   #81
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Default seq more information

Originally Posted by srasdk View Post
In resequencing ~90% of raw sequences perfectly match the reference.
1. Will you supply bibliographic citation for this observation?

Originally Posted by srasdk View Post
When this cost will be low enough to make archival economically senseless, it will stop.
2. What will do for comparative biological/phylogenetic studies?

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Old 09-28-2011, 08:07 PM   #82
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1. The observation is general and not precise. It was done while working with the recent 1000 Genomes data. Sorry - the statement was too broad. Homo sapiens is a very inbred species and any personal germline genome is very close to the reference. Somatic changes (cancer) are more unpredictable. If you are interested in in biological diversity other then human, then you were right in confronting the statement, but currently NGS data production is heavily tilted toward human.

2. Before NGS phylogenetic studies were submitted as final and annotated sequences to GenBank. When community becomes confident that it can extract most of the information from raw data, there will be no point of archiving intermediate results.
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Old 10-20-2011, 11:04 AM   #83
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