Is there a way to turn off the normalisation by the library size (either full or effective) in DiffBind?
The problem is that I the bam files I want to use are already normalised in a specific way which I don't want to change. I am looking for the way to turn off the normalisation in DiffBind. I found the option SCORE which can be DBA_RAW_READS, but it doesn't seem to affect subsequent differential analysis by any of the methods available. Does anyone know the way around this problem?
The problem is that I the bam files I want to use are already normalised in a specific way which I don't want to change. I am looking for the way to turn off the normalisation in DiffBind. I found the option SCORE which can be DBA_RAW_READS, but it doesn't seem to affect subsequent differential analysis by any of the methods available. Does anyone know the way around this problem?
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