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  • ChIP-seq annotation bidirectional promoters: any tool?

    Hi all,

    I am annotating peaks from a ChIP-seq experiment.

    The problem I face is that some of the peaks fall on bidirectional promoters.

    I would like to be able to get an output annotation that gives me information about the nearest TSS on the + strand AND on the - strand, and not only selecting the closest one, regardless of the strand.

    I don't think HOMER can do this (correct me if I'm wrong), and also tried ChIPpeakAnno and ChIPseeker but I would like to know if there is a tool that could be advised in that context?

    Thanks a lot!
    Sarah

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