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  • PubMed: Recognition tunneling.

    Syndicated from PubMed RSS Feeds

    Recognition tunneling.

    Nanotechnology. 2010 Jun 4;21(26):262001

    Authors: Lindsay S, He J, Sankey O, Hapala P, Jelinek P, Zhang P, Chang S, Huang S

    Single molecules in a tunnel junction can now be interrogated reliably using chemically functionalized electrodes. Monitoring stochastic bonding fluctuations between a ligand bound to one electrode and its target bound to a second electrode ('tethered molecule-pair' configuration) gives insight into the nature of the intermolecular bonding at a single molecule-pair level, and defines the requirements for reproducible tunneling data. Simulations show that there is an instability in the tunnel gap at large currents, and this results in a multiplicity of contacts with a corresponding spread in the measured currents. At small currents (i.e. large gaps) the gap is stable, and functionalizing a pair of electrodes with recognition reagents (the 'free-analyte' configuration) can generate a distinct tunneling signal when an analyte molecule is trapped in the gap. This opens up a new interface between chemistry and electronics with immediate implications for rapid sequencing of single DNA molecules.

    PMID: 20522930 [PubMed - as supplied by publisher]



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