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Old 07-26-2013, 01:47 PM   #1
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Default WGA techniques

I am new in NGS. I am wondering if anybody knows the difference between 2 WGA methods:

MALBAC of Sunney Xie


Rubicon's PicoPlex

I thought they are similar, but I could be wrong.
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Old 08-17-2013, 05:56 PM   #2
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Default WGA, MALBAC and Rubicon

Our blog post describes several single cell sequencing approaches. For more details check out their patents:


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Old 04-06-2018, 01:50 AM   #3
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They are all good when you have "few" cells, like 10 or more, but all suffer when you have a "single" cell. Mostly you will experience high allelic dropout and high noise in Copy number profiles. Currently, the method which is reported by multiple comparative articles to be the best performer for "single" cell WGA is Ampli1
PLOS ONE | March 1, 2018
PLOS ONE | DOI:10.1371/journal.pone.0171566 February 16, 2017
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