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  • Just how much is genetic related anyway?

    Roberts et al have analyzed large cohorts of monozygotic twins to try and determine the theoretical limits of how useful genomic sequencing can be.

    New DNA sequencing methods will soon make it possible to identify all germline variants in any individual at a reasonable cost. However, the ability of whole-genome sequencing to predict predisposition to common diseases in the general population is unknown. To estimate this predictive capacity, we …


    Amid the breathless anticipation about the $1000 genome and beyond, it is sobering to remember what we knew all along: there is PLENTY of environmental effects on how we turn out.

    Even if we could sequence and analyze genomes for negligible cost, there still remains a significant hurdle: lack of knowledge about what genetic variation really means for phenotype.

    I guess we should be happy: our jobs are safe for the foreseeable future.
    Kamalakar Gulukota,
    Director,
    Center for Bioinformatics and Computational Biology
    NorthShore University Health System, [email protected]

  • #2
    Hi Gulu,

    I think newborn screening applications (for detecting and treating the many treatable genetic diseases at birth) will be a good start. US state public health departments are recognizing the potential of switching from gene panels to whole genome sequencing.

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