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1. A comprehensive analyses for the expression profile, clinical outcomes, somatic copy number alterations (SCNAs) profile of long non-coding genes(lncRNAs) in ~7000 clinical RNA-Seq data/samples from 15 different cancer types from TCGA.
2. We identified significantly differentially expressed lncRNAs between tumor and normal tissues from each cancer. Notably, we characterized 47 lncRNAs which were extensively dysregulated in at least 10 cancer types.
3. We also analyzed the associations between lncRNA expressions and patient survival, and identified sets of lncRNAs that possessed significant prognostic values in specific cancer types.
4. Our combined analysis of SCNA data and expression data uncovered 116 potential driver lncRNAs are strikingly genomic altered across 15 cancer types.
Paper: Integrative analysis reveals clinical phenotypes and oncogenic potentials of long non-coding RNAs across 15 cancer types. Oncotarget. 2016 Apr 27.
driver lncRNA genes:
2. We identified significantly differentially expressed lncRNAs between tumor and normal tissues from each cancer. Notably, we characterized 47 lncRNAs which were extensively dysregulated in at least 10 cancer types.
3. We also analyzed the associations between lncRNA expressions and patient survival, and identified sets of lncRNAs that possessed significant prognostic values in specific cancer types.
4. Our combined analysis of SCNA data and expression data uncovered 116 potential driver lncRNAs are strikingly genomic altered across 15 cancer types.
Paper: Integrative analysis reveals clinical phenotypes and oncogenic potentials of long non-coding RNAs across 15 cancer types. Oncotarget. 2016 Apr 27.
driver lncRNA genes: