Hello all.
I am always enjoying this site and this is my first posting.
Now I am interested in epigenetics of lymphocytes.
For analyzing the influence of gene-deletion (knock out) on epigenetics
I would like to use genetically modified mice whose back ground is
balb/c not c57bl/g/6. But reference sequence information mm9 is
mainly made by sequencing C57BL/6j mice.
So I am worrying about the genetic difference between
balb/c and C57bl/6. Maybe important region is conserved, but there
are several regions not conserved between c57bl/6 and balb/c.
If there is anyone who have experience of analyzing balb/c with
chip-seq or medip-seq, Please advise me on this issue.
Thank you for your time.
I am always enjoying this site and this is my first posting.
Now I am interested in epigenetics of lymphocytes.
For analyzing the influence of gene-deletion (knock out) on epigenetics
I would like to use genetically modified mice whose back ground is
balb/c not c57bl/g/6. But reference sequence information mm9 is
mainly made by sequencing C57BL/6j mice.
So I am worrying about the genetic difference between
balb/c and C57bl/6. Maybe important region is conserved, but there
are several regions not conserved between c57bl/6 and balb/c.
If there is anyone who have experience of analyzing balb/c with
chip-seq or medip-seq, Please advise me on this issue.
Thank you for your time.
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