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Old 10-30-2018, 06:12 AM   #1
mararie
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Location: Oslo, Norway

Join Date: May 2014
Posts: 2
Default PhD student position in computational biology and systems medicine, uni of oslo

Job description
The Computational Biology and Systems Medicine group (Kuijjer group) at the Centre for Molecular Medicine Norway (NCMM), a Nordic EMBL partner, and the University of Oslo is looking for a PhD candidate. The position is available immediately. The appointment will be for three years.

The Computational Biology and Systems Medicine group investigates how gene regulatory networks are disrupted in cancer. We do this by building computational tools that model networks of gene regulation, which represent for example how transcription factors or microRNAs regulate genome-wide gene expression. Using high-performance computing, we can model these networks for each individual sample in large-scale cancer `omics datasets. We then analyze these “big data” networks using statistical methods. This allows us to better understand both the system-wide level of changes, as well as specific disruptions in regulation that may drive cancer development, progression, and response to treatment.

More about the position
The fellowship period is 3 years and is devoted to carrying out one of the following projects.

The first project focuses on the computational aspect of our research. This project aims to develop tools to correctly model gene regulation and to build gene regulatory networks. The candidate will both expand current tools (see https://www.kuijjerlab.org/tools/) and will develop new tools for network inference of different types of transcriptional and post-transcriptional gene regulation. The candidate will thoroughly test these methods on various human `omics datasets.

The second project will largely focus on the bioinformatic/analytic aspect of our research. The aim will be to drive new discoveries in cancer research by big data modeling of gene regulation in individual cancer samples. The outcome of this project will be to identify new gene regulatory biomarkers and specific candidates for personalized treatment. We will do this for individual cancer types (we have a specific interest in sarcomas), as well as on studying pan-cancer gene regulation.

As a PhD candidate you will be working under the direct supervision of Dr. Marieke Kuijjer (see kuijjerlab.org). The PhD candidate must take part in the University’s approved PhD program and is expected to complete the project within the set fellowship period. The main purpose of the fellowship is research training leading to the successful completion of a PhD degree. There will be opportunities to start collaborations with other research groups at UiO and institutes abroad (we currently collaborate with groups at Harvard Chan School of Public Health and Leiden University Medical Center).

Qualification requirements
  • Master’s degree or equivalent in computational biology, bioinformatics, cancer genomics, (bio)physics, computer science, statistics, or a related field. We are an interdisciplinary team and welcome students who want to expand their knowledge in either biology or computation.
  • Proficient in programming and/or scripting languages, such as R, Python, Matlab.
  • Good analytical skills.
  • Knowledge of statistics.
  • Documented ability to write scientific manuscripts.
  • Fluent oral and written communication skills in English.
  • Excellent communication skills.
  • Ability to work in a team environment.
Desirable skills:[*]Previous experience with genomic data analysis[*]Experience with high-performance computing

We offer[*]salary NOK 449 400 – 505 800 per annum depending on qualifications in a position as PhD Research fellow, (position code 1017)[*]attractive welfare benefits and a generous pension agreement, in addition to Oslo’s family-friendly environment with its rich opportunities for culture and outdoor activities

How to apply
The application must include:
  • cover letter including a statement of motivation, scientific background, and research interests. Please include information on which of the two projects you prefer.
  • CV (summarizing education, positions and academic work)
  • copies of educational certificates (academic transcripts only)
  • a complete list of publications and academic works
  • list of reference persons: 2-3 references (name, relation to candidate, e-mail and phone number)
The application with attachments must be delivered in our electronic recruiting system, https://www.jobbnorge.no/en/availabl...stems-medicine. Please follow the link “apply for this job”. Foreign applicants are advised to attach an explanation of their University's grading system. Please note that all documents should be in English.

When evaluating the application, emphasis will be given to the applicant’s academic and personal prerequisites to carry out the project. Interviews with the best qualified candidates will be arranged.

Formal regulations
Please see the guidelines and regulations for appointments to Research Fellowships at the University of Oslo. According to the Norwegian Freedom and Information Act (Offentleglova) information about the applicant may be included in the public applicant list, also in cases where the applicant has requested non-disclosure. The appointment may be shortened/given a more limited scope within the framework of the applicable guidelines on account of any previous employment in academic positions. The University of Oslo has an agreement for all employees, aiming to secure rights to research results etc.

Contact information
Please contact Dr. Marieke Kuijjer, email address: marieke.kuijjer at ncmm.uio.no with questions on the project and position. For questions relating to the administrative aspects of the application, please contact Ragni Indahl ragni.indahl at ncmm.uio.no

About the University of Oslo
The University of Oslo is Norway’s oldest and highest ranked educational and research institution, with 28 000 students and 7000 employees. With its broad range of academic disciplines and internationally recognised research communities, UiO is an important contributor to society.

Centre for Molecular Medicine Norway (NCMM) was established in 2008 and is the Norwegian node in the Nordic EMBL Partnership for Molecular Medicine. NCMM is a joint venture between the University of Oslo, Health Region South-East and the Research Council of Norway. From 2017 NCMM is merged with the Biotechnology Centre of Oslo and now has altogether 11 research groups. The overall objective of NCMM is to conduct cutting edge research in molecular medicine and biotechnology as well as facilitate translation of discoveries in basic medical research into clinical practice.
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