Dear members
I used VEP (Variant Effect Predictor) tool to annotate SNPs. I used the option "--sift b" to obtain SIFT scores, such as tolerated or deleterious SNPs.
From the SIFT paper, they recommend "Deleterious (sift<=0.05) and tolerated (sift>0.05)."
But in other paper they considered one SNP tolerated with SIFT score = 0.05
From my the VEP results I had SNPs tolerated with SIFT score = 0.05 and also SNPs with deleterious effect with 0.05 score. This is correct?
I am confusing! A SNP with SIFT score = 0.05 is deleterious or tolerated?????
thanks
Clarissa
I used VEP (Variant Effect Predictor) tool to annotate SNPs. I used the option "--sift b" to obtain SIFT scores, such as tolerated or deleterious SNPs.
From the SIFT paper, they recommend "Deleterious (sift<=0.05) and tolerated (sift>0.05)."
But in other paper they considered one SNP tolerated with SIFT score = 0.05
From my the VEP results I had SNPs tolerated with SIFT score = 0.05 and also SNPs with deleterious effect with 0.05 score. This is correct?
I am confusing! A SNP with SIFT score = 0.05 is deleterious or tolerated?????
thanks
Clarissa
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