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Old 07-02-2010, 05:54 AM   #1
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Location: Oxford

Join Date: Jul 2010
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Default Senior Fellow in Computational Genomics

Career Development Fellow in Computational Genomics

University of Oxford - Oxford Parkinsonís Disease Centre

Grade 7: Salary £28,983Ė£35,646 pa (with discretionary points to £38,951)

Applications are invited for a Postdoctoral Career Development Fellow to work at the heart of a cutting-edge multi-disciplinary initiative, the Oxford Parkinsonís Disease Centre (OPDC).

The Fellow will work across a highly collaborative project to identify and understand the genes and pathways that underlie Parkinsonís disease. Research will be centered on the laboratory of Professor Chris Ponting (MRC Functional Genomics Unit, Le Gros Clark Building, University of Oxford, South Parks Road, Oxford OX1 3QX) but will reach out to clinicians, physiologists and cellular and molecular biologists within the consortium.

The genetics underlying Parkinsonís disease (PD) remain largely unknown. Our approach to understanding PD is to apply newly-developed computational methods to the vast population data sets from patient and control individuals that are being generated using the newest genomic technologies. Together we will seek to accurately predict pathways, genes and variants that underlie the etiology of PD.

The successful candidate will drive their own research program with a central role in generating new hypotheses on the causes of PD. In this, s/he will be supported by a vibrant computational genomics group with considerable experience in diverse genomic analyses.

Alongside public data, s/he will have access to a large novel dataset of exomes sequenced from a cohort of PD patients and will aim to identify novel PD candidate genes and biological processes. Novel leads will be investigated subsequently in partnership with OPDC members who are experts in a diverse range of cutting-edge techniques, from transgenics to MRI to iPS cells.

Genomics is a very rapidly moving field and the successful candidate will harness emerging functional genomics resources to complement existing knowledge. In particular, s/he will employ functional network information, such as shared biological pathways or phenotypes, to identify candidate genes.

Applicants must have a doctorate in a relevant area of research, such as computational biology, bioinformatics, statistical genetics or comparative genomics. Applicants should be able to script competently, and have experience of current bioinformatics tools, resources, and method development. Evidence of leading and managing successful research projects will also be required.

For further information about the Oxford Parkinsonís Disease Centre may be found at:

Informal enquiries may be directed to Dr Caleb Webber on or Prof. Chris Ponting on

Further particulars and details of how to apply are available at or email

The post is funded by the Monument Discovery Award from Parkinsonís UK. The post is available immediately and is offered for a period of five years.

Please quote reference no: AV10019. The closing date for applications is noon on 10 August 2010.
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