Tweet
How can I know that a shown de novo mutation is really a right positive de novo mutation?
How I can know that a shown de novo mutation is false positive?
How I can know that a shown de novo mutation is false positive?
-
-
You can visualize it.
Often visualization of a region around a snp can give a good clue as to what's going on.
Some are "slam dunks", others are "well .. maybe" and others are "nope".
I suspect that attempts to make 99% accurate calling is frustrated by several things: repeats, homo-polymer runs, inaccurate reference, near duplicate regions, chemistry problems, etc. It takes a bit of practice, but a quick, but knowledgeable eye can spot some problems. -
cause
Because there is a terrible genetic problem in my case. Something biochemocally is going wrong in my body. There is a defective gene in my genome. Sbould be idemtified to success further in life. There os the possibility that a de novp mitation causes it.
I showed terroble gender atypical behavior when I was younger almost transsexuality. I also do look weird on class photos.
No doubt a genetic trouble is existing!Last edited by Mr.Zurich1992; 04-13-2016, 02:19 PM.Comment
-
The field of epigenetics has traditionally concentrated more on DNA and how changes like methylation and phosphorylation of histones impact gene expression and regulation. However, our increased understanding of RNA modifications and their importance in cellular processes has led to a rise in epitranscriptomics research. “Epitranscriptomics brings together the concepts of epigenetics and gene expression,” explained Adrien Leger, PhD, Principal Research Scientist on Modified Bases...Yesterday, 07:01 AM -
Proteins are often described as the workhorses of the cell, and identifying their sequences is key to understanding their role in biological processes and disease. Currently, the most common technique used to determine protein sequences is mass spectrometry. While still a valuable tool, mass spectrometry faces several limitations and requires a highly experienced scientist familiar with the equipment to operate it. Additionally, other proteomic methods, like affinity assays, are constrained...04-04-2024, 04:25 PM
Comment