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Old 11-04-2008, 05:03 AM   #1
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Default PubMed: An integrated software system for analyzing ChIP-chip and ChIP-seq data.

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Related Articles An integrated software system for analyzing ChIP-chip and ChIP-seq data.

Nat Biotechnol. 2008 Nov 2;

Authors: Ji H, Jiang H, Ma W, Johnson DS, Myers RM, Wong WH

We present CisGenome, a software system for analyzing genome-wide chromatin immunoprecipitation (ChIP) data. CisGenome is designed to meet all basic needs of ChIP data analyses, including visualization, data normalization, peak detection, false discovery rate computation, gene-peak association, and sequence and motif analysis. In addition to implementing previously published ChIP-microarray (ChIP-chip) analysis methods, the software contains statistical methods designed specifically for ChlP sequencing (ChIP-seq) data obtained by coupling ChIP with massively parallel sequencing. The modular design of CisGenome enables it to support interactive analyses through a graphic user interface as well as customized batch-mode computation for advanced data mining. A built-in browser allows visualization of array images, signals, gene structure, conservation, and DNA sequence and motif information. We demonstrate the use of these tools by a comparative analysis of ChIP-chip and ChIP-seq data for the transcription factor NRSF/REST, a study of ChIP-seq analysis with or without a negative control sample, and an analysis of a new motif in Nanog- and Sox2-binding regions.

PMID: 18978777 [PubMed - as supplied by publisher]



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