Donor-Participants species probability

papori · 05-10-2020, 12:57 AM

Hi all,
We are doing a microbiome study with FMT (Fecal Microbiota transplant), and I have a statistic question about something we found.

Background
In the experiment there are 2 donors and 11 recipients.
Donor 1 group are 6 participants
Donor 2 group are 5 participants

Result of FMT
In Donor 1 group we have 3 responders, and 3 non responders
In Donor 2 group we have 0 responders, and 5 non responders

We found that there is only one species that is in Donor 1 and in the 3 responders, but not found in the rest.
We suspect that this species can be a marker for matching Donor-Participant for being a responder.
We have 200 species in all the samples together.

Question
I would like to calculate the probability for this, and I believe Bayes probability is the way.
I think that I know how to ask the question, but not to do the calculation and I will appreciate your help:

What is the likelihood to be this species that found only in Donor 1 and in his responders, when I have only 3 responders out of 11 participants and 2 Donors?

Thanks for the reading, and I hope to understand it ��

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05-10-2020, 12:57 AM	#1
papori Senior Member Location: berd Join Date: Dec 2010 Posts: 181	Donor-Participants species probability Hi all, We are doing a microbiome study with FMT (Fecal Microbiota transplant), and I have a statistic question about something we found. Background In the experiment there are 2 donors and 11 recipients. Donor 1 group are 6 participants Donor 2 group are 5 participants Result of FMT In Donor 1 group we have 3 responders, and 3 non responders In Donor 2 group we have 0 responders, and 5 non responders We found that there is only one species that is in Donor 1 and in the 3 responders, but not found in the rest. We suspect that this species can be a marker for matching Donor-Participant for being a responder. We have 200 species in all the samples together. Question I would like to calculate the probability for this, and I believe Bayes probability is the way. I think that I know how to ask the question, but not to do the calculation and I will appreciate your help: What is the likelihood to be this species that found only in Donor 1 and in his responders, when I have only 3 responders out of 11 participants and 2 Donors? Thanks for the reading, and I hope to understand it �� Last edited by papori; 05-10-2020 at 02:33 AM.