GeneSpring webinar- Uncovering mechanisms of Hepatotoxicity

Strandlife · 05-23-2017, 04:39 AM

Uncovering Mechanisms of Hepatotoxicity for High Affinity Antisense Oligonucleotides – 3’ end RNA-seq Profiling Using GeneSpring GX
High affinity antisense oligonucleotides (ASOs) containing bicylic modifications (BNA) such as locked nucleic acid (LNA) or constrained ethyl (cEt) designed to induce target RNA cleavage have been shown to have enhanced potency along with a higher propensity to cause hepatotoxicity. In order to unravel the mechanism of this hepatotoxicity, we leveraged GeneSpring GX analysis software to analyze transcriptional profiles from the livers of mice treated with a panel of highly efficacious hepatotoxic or non-hepatotoxic LNA ASOs.

Speaker Name
Sebastien A. Burel, PhD
Director, Nonclinical Development
Ionis Pharmaceuticals
Carlsbad, California 92010

Session details
Wednesday, June 14, 2017, 8:00 a.m. PST

Register here

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05-23-2017, 04:39 AM	#1
Strandlife strandlife Location: All over the world Join Date: May 2013 Posts: 67	GeneSpring webinar- Uncovering mechanisms of Hepatotoxicity Uncovering Mechanisms of Hepatotoxicity for High Affinity Antisense Oligonucleotides – 3’ end RNA-seq Profiling Using GeneSpring GX High affinity antisense oligonucleotides (ASOs) containing bicylic modifications (BNA) such as locked nucleic acid (LNA) or constrained ethyl (cEt) designed to induce target RNA cleavage have been shown to have enhanced potency along with a higher propensity to cause hepatotoxicity. In order to unravel the mechanism of this hepatotoxicity, we leveraged GeneSpring GX analysis software to analyze transcriptional profiles from the livers of mice treated with a panel of highly efficacious hepatotoxic or non-hepatotoxic LNA ASOs. Speaker Name Sebastien A. Burel, PhD Director, Nonclinical Development Ionis Pharmaceuticals Carlsbad, California 92010 Session details Wednesday, June 14, 2017, 8:00 a.m. PST Register here