MiSeq boots to grey screen with mouse cursor

[cement_head]

We just had our MiSeq fail. System lockup and then a hard reboot/reset gets me to a grey screen with a mouse cursor - no response.

I suspect a Windows configuration file corruption. Anyone see this before?

[GenoMax]

It could also be some hardware failure (either on the computer side or MiSeq electronics). Time to put that service contract (you have one right?) to use.

BTW: What was it doing (running/idling) when it failed?

[cement_head]

It could also be some hardware failure (either on the computer side or MiSeq electronics). Time to put that service contract (you have one right?) to use.

BTW: What was it doing (running/idling) when it failed?

It locked up and we had to do a hard reboot.

We figured it out with the help of our SC @ Illumina: It was a boot configuration file that got overwritten by a Windows O/S update. Basically the MCS software and the O/S were having a fight, resulting in a grey screen. Re-writing the config file to let the Windows system to fully boot and delay loading the MCS for 30 seconds solved the issue.

It appears that Microsoft has implimented changes / installs / overwrites a configuration file with no regard for local system configuration.

[GenoMax]

Good to know. Hopefully this will help someone else.

This is one reason we never bother with windows updates on our sequencers. They are isolated from network though.

[thermophile]

ug that's delightful. Thanks for reporting your experience, hasn't happened here yet because I think I've managed to turn off all updates (yes I know that is a security risk)

[lac302]

This is why I've kept ours offline. Good to hear it was a simple solution

[salyamoff]

Try connect keyboard, press Alt+Ctrl+Del and run Explorer.exe in windows task manager. Then kill all Illumina processes and run program.