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I'm wondering if there is a comprehensive database for RNA-Seq data from different mouse tissues similar to what Novartis GNF Symatlas generated? If so, any literature that describes such a database?
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RNA-Seq database?
I still haven't been able to find a comprehensive database containing RNA-Seq data for the majority of tissues/cells in mice, similar to what GNF performed using a microarray platform. I found a paper below which contains a few samples, but it would be helpful to identify larger sets of data.
PMID: 22345621
"RNA-Seq Atlas--a reference database for gene expression profiling in normal tissue by next-generation sequencing"
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The field of epigenetics has traditionally concentrated more on DNA and how changes like methylation and phosphorylation of histones impact gene expression and regulation. However, our increased understanding of RNA modifications and their importance in cellular processes has led to a rise in epitranscriptomics research. “Epitranscriptomics brings together the concepts of epigenetics and gene expression,” explained Adrien Leger, PhD, Principal Research Scientist on Modified Bases...Yesterday, 07:01 AM -
Proteins are often described as the workhorses of the cell, and identifying their sequences is key to understanding their role in biological processes and disease. Currently, the most common technique used to determine protein sequences is mass spectrometry. While still a valuable tool, mass spectrometry faces several limitations and requires a highly experienced scientist familiar with the equipment to operate it. Additionally, other proteomic methods, like affinity assays, are constrained...04-04-2024, 04:25 PM
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