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Variance decomposition in DESeq2 Golsheed Bioinformatics 13 11-05-2014 11:44 AM
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Old 11-03-2014, 09:42 AM   #1
Location: Montreal

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Default Variance Decomposition in DESeq2

I was wondering whether using the partial coefficient of determination is appropriate for variance decomposition, when using DESeq2? In other words, I want to calculate the proportion of variance (in the observed data; i.e., read counts) explained by each covariate in the model.
I basically want to know the following
(1) is it a good and meaningful measure or not, considering we're dealing with a glm?
(2) is there a way I can achieve equivalent information by handling "deviances" instead?
Any comment or hint would be appreciated. Also, I'd appreciate if anyone could suggest a good reference book or paper on this.
Thanks a bunch!
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Old 11-05-2014, 05:20 AM   #2
Michael Love
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