Hi All,
In RNASeq, we usually do not reduce identical alignments of multiple reads in a specific position to single read, this is because de-duplication would not let us analyze highly expressed transcripts.
Is this the same case with Bisulfite-Seq methylation data?.
I notice from the following two links (first for rna-seq, second for methylation) that for methylation, they de-duplicate, however, in rna-seq they do not.
In RNASeq, we usually do not reduce identical alignments of multiple reads in a specific position to single read, this is because de-duplication would not let us analyze highly expressed transcripts.
Is this the same case with Bisulfite-Seq methylation data?.
I notice from the following two links (first for rna-seq, second for methylation) that for methylation, they de-duplicate, however, in rna-seq they do not.