ChIP - shearing with the Covaris S2

[ETHANol]

I've been doing some optimization work with ChIP and the Covaris S2. I figure some people would probably be interested. All in all it appears to be a great instrument. Fragmentation of the chromatin is really even without bias towards open chromatin which is important for ChIP-seq. My only complaint is that it only takes one sample at a time, so if you have a lot of samples to process it can take a good amount of time. But the reproducibility is worth the extra time.

Anyway, it's too much to post here but it's on my blog at:

http://ethanomics.wordpress.com/2011/11/30/177/

http://ethanomics.wordpress.com/2011/12/28/202/

http://ethanomics.wordpress.com/chip-fragmentation-with-covaris-protocol/

Thanks to Hamid at Covaris for his help. Phenomenal customer support.

[Liting]

Why I can't open the Links?
Can you give me the new links?Thanks !

[ETHANol]

The links seem to be fine. Are you still having this problem? Send me a PM if you like.