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  • Samples with a mixture of cells

    Hi list,

    I have a question regarding samples with a mixture of cells, for example tumor samples with a mixture of healthy and tumor cells. So affected cells might have a deletion of one allele, while healthy cells will have both copies. Can NGS make them apart? How can one make calls for heterozygous deletions and get differences in copy number?
    I guess it is important to select samples with the maximum uffacted/unaffected cells ratio but still sometimes it is difficult to get a good sample.
    How are you handling this kind of analysis?

    Looking forward to your comments

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