To score a sequence alignment, the distribution of local alignment scores involving random sequences is used as a statistical reference.
What are some current techniques used by computational biologists in estimating the parameters of such distributions? How does this distribution vary with different species? Or maybe I should ask: how do we take into account of the differences between species when modeling these distributions?
I recently came across the "island method" approach but I don't quite understand it. > < Could someone please offer a short explanation?
Are there example implementations or opensource codes of these parameter estimation methods I could check out?
Thank you very much
What are some current techniques used by computational biologists in estimating the parameters of such distributions? How does this distribution vary with different species? Or maybe I should ask: how do we take into account of the differences between species when modeling these distributions?
I recently came across the "island method" approach but I don't quite understand it. > < Could someone please offer a short explanation?
Are there example implementations or opensource codes of these parameter estimation methods I could check out?
Thank you very much
Comment