I am trying to detect somatic CNV using matched tumor/normal exome sequencing data.
I found that popular tools such as EXCAVATOR, ExomeCNV etc require tumor fraction or cellularity as an input parameter.
At the same time, tumor fraction estimation tools such as THetA require CNV result as input.
Could anyone recommend a simple tool that could estimate tumor fraction without using CNV data, or a CNV detection tool with built-in function to estimate tumor fraction?
I found that popular tools such as EXCAVATOR, ExomeCNV etc require tumor fraction or cellularity as an input parameter.
At the same time, tumor fraction estimation tools such as THetA require CNV result as input.
Could anyone recommend a simple tool that could estimate tumor fraction without using CNV data, or a CNV detection tool with built-in function to estimate tumor fraction?
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