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Old 07-12-2012, 07:11 PM   #1
genelab
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Smile Deleterious information in dbSNP

Hello everyone,
How could I obtain the SNPs which are deleterious in the dbSNP?

Is the recent versions of dbSNP containing the deleterious information if the SNP sites is deleterious?


Thanks a lot!
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Old 07-12-2012, 07:15 PM   #2
ymc
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ftp://gsapubftp-anonymous@ftp.broadi...35.hg19.vcf.gz

SNPs with alternate allele shorter than the reference allele are deletions
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Old 07-12-2012, 09:08 PM   #3
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Quote:
Originally Posted by ymc View Post
ftp://gsapubftp-anonymous@ftp.broadi...35.hg19.vcf.gz

SNPs with alternate allele shorter than the reference allele are deletions
thanks for you reply~

my purpose is to obtain the deleterious snp sits.

Any body knows ?


Many thanks~
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Old 07-13-2012, 01:50 AM   #4
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Quote:
Originally Posted by genelab View Post
thanks for you reply~

my purpose is to obtain the deleterious snp sits.

Any body knows ?


Many thanks~
snp position is also in the vcf file
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Old 07-13-2012, 10:31 AM   #5
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Based on my understanding of your question, do this:

Go to: http://www.ncbi.nlm.nih.gov/snp/limits

Choose organism and then under annotation, check "clinical/lsdb submissions" and also choose "pathogenic" and "probably pathogenic". Hit Search.

You can download it in a format you want using "display settings" on left top.
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