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Old 05-14-2019, 12:11 PM   #1
eab
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Location: Maryland

Join Date: May 2011
Posts: 66
Default How to make oligo-dT bind tighter

Has anyone tried chemical modifications to oligo-dT-VN to increase binding affinity to mRNA molecules? For example, are LNA bases helpful? We're developing a bead-based mRNA recovery method, and want both to improve our yield and to decrease RNA exchange between beads.
Thanks!
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