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Old 12-19-2009, 08:18 AM   #1
HTS
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Location: Toronto

Join Date: Nov 2009
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Default Sequencing bias on the Illumina platform

Hi,

I am trying to take a close look at the sequencing bias present in the Illumina platform and to think about ways to correct for it algorithmically, especially in the context of RNA-Seq. My main reference so far is the transcript length bias study by Oshlack and Wakefield. Does anyone know more recent/comprehensive studies and/or up-to-date information? Any helpful suggestions will be greatly appreciated. Thanks a lot!

-- Leo
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