Would there be a way to create a consensus bam from multiple input bam files without skewing coverage to a ridiculous size?
Say I had several bams from exome sequencing of the exact same sample. It is my understanding that if I merge these files my overall coverage would be really high. Instead I might want to merge them but average the coverage across the bams rather then add them, however I can not think of a way to merge bam files in this way.
Thanks.
Say I had several bams from exome sequencing of the exact same sample. It is my understanding that if I merge these files my overall coverage would be really high. Instead I might want to merge them but average the coverage across the bams rather then add them, however I can not think of a way to merge bam files in this way.
Thanks.
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