Hello All,
Strelka is a new workflow available to call SNVs and small indels from sequencing data for matched tumor-normal samples. It is designed to detect somatic variants at lower frequencies typically encountered in tumors due to sample impurity or sub-clone variation. The workflow also provides computational efficiency appropriate for the whole genome sequencing case: requiring ~1 core-hour per 2x combined tumor normal coverage.
More information/source code available here:
https://sites.google.com/site/strelk...cvariantcaller
We appreciate any feedback on how these methods can be improved.
Best Regards,
-Chris Saunders
Strelka is a new workflow available to call SNVs and small indels from sequencing data for matched tumor-normal samples. It is designed to detect somatic variants at lower frequencies typically encountered in tumors due to sample impurity or sub-clone variation. The workflow also provides computational efficiency appropriate for the whole genome sequencing case: requiring ~1 core-hour per 2x combined tumor normal coverage.
More information/source code available here:
https://sites.google.com/site/strelk...cvariantcaller
We appreciate any feedback on how these methods can be improved.
Best Regards,
-Chris Saunders
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