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If you're just browsing the human genome sequence you may get a false impression of the content of Ns since there are huge streches of poly-N at both the telomeres and centromeres of every chromosome. These regions are particularly repetitive and almost impossible to assemble. The Ns on the end are just there so that the overall chromosome length shown is roughly correct.
Other than that internal Ns are now relatively infrequent and generally represent short, highly repetitive regions.
Compared to the assemblies of a lot of other vertebrate species though the human genome is very complete and accurate!
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by seqadmin
The sequencing world is rapidly changing due to declining costs, enhanced accuracies, and the advent of newer, cutting-edge instruments. Equally important to these developments are improvements in sequencing analysis, a process that converts vast amounts of raw data into a comprehensible and meaningful form. This complex task requires expertise and the right analysis tools. In this article, we highlight the progress and innovation in sequencing analysis by reviewing several of the...-
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05-06-2024, 07:48 AM -
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by seqadmin
The field of epigenetics has traditionally concentrated more on DNA and how changes like methylation and phosphorylation of histones impact gene expression and regulation. However, our increased understanding of RNA modifications and their importance in cellular processes has led to a rise in epitranscriptomics research. “Epitranscriptomics brings together the concepts of epigenetics and gene expression,” explained Adrien Leger, PhD, Principal Research Scientist...-
Channel: Articles
04-22-2024, 07:01 AM -
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